Our lab is looking for a highly motivated and collaborative PhD student to join our team in leading an exciting project related to the development of new genetically-encoded tools to investigate GPCR signaling at the systems level. REQUIREMENTS: • Master’s degree in Biotechnology, Biochemistry, Bioengineering, Molecular Biology or a related discipline. • An ideal candidate should have solid experience in 2 or more of the following techniques: molecular cloning, protein expression/purification in bacteria, mammalian cell culture, fluorescence microscopy • Good organizational skills, attention to details, reliability, and ability to work in an diverse team. • Excellent speaking/writing skills (in English)

We are looking for talented and motivated postdoctoral researchers with a strong interest in genome organization and regulation. The position is funded by a prestigious ERC Starting grant (3D-REG “Shedding light on three-dimensional gene regulation”) that was recently awarded to Marieke Oudelaar. The project will involve a combination of approaches based on molecular and computational biology and will be tailored to the specific interests of the successful candidate.

We are recruiting team-oriented & accomplished scientists (Postdoc level). You are driven, goal-oriented and determined to make your mark. We are pursuing mechanistic-based research which leverages on the power of human genetics, going from whole (epi)genome sequencing, gene discovery, patient-derived organoid and animal models. We seek to develop cell-based CRISPR and HTS screens for hit generation to lead optimization towards preclinical drug development. We are looking for scientists that want to realize bedside to bench and back paradigms. If you are exceptionally determined whatever your skill may be (e.g. CryoEM, CRISPR screen, drug design, mechanistic studies, etc..) , don't hesitate to reach out.

We are looking for a prospective colleague with: • Outstanding scientific achievements in any field of neurophysiology, • Success in attracting competitive funding, • Leadership experience, • Experience in interdisciplinary cooperation, • Mentoring and teaching competence.

A postdoctoral position is available in the laboratory of Prof. Petr Broz in the Department of Immunobiology, University of Lausanne, Switzerland. The Broz lab investigates the innate immune signaling pathways that allows cells to detect and respond to infections with pathogenic microorganisms. A particular focus of the lab is the inflammasome, a multi protein signaling platform that is assembled by pattern recognition receptors upon detection of pathogen- or host-derived danger signals, and which controls the release of cytokines and the induction of pyroptosis, a lytic for of cell death. • Expected start date: Flexible. Starting in Summer/Autumn 2024, or to be agreed on • Employment rate: 100% • Place of work: Dpt. of Immunobiology, UNIL, Chemin des Boveresses 155, 1066 Epalinges, Switzerland, Specific Project/s: We are seeking a postdoctoral researcher to study inflammasome-dependent host defenses against bacterial and viral pathogens in intestinal organoid and/or in vivo models.

The CRG is recruiting a Bioinformatician with experience in genomics pipeline development and database infrastructure. The position will entail developing computational pipelines for the processing of novel and existing single-cell transcriptomic datasets from diverse species across the tree of life, as well as developing a comparative cell atlas database. The candidate will be a part of a highly interdisciplinary team that includes computational, evolutionary, and molecular biologists in different groups at CRG (including the Bioinformatics Unit), and this project will be developed in very close contact with groups at EMBL-EBI (Hinxton, UK) and at the Earlham Institute (Norwich, UK).

The surface of the brain is connected to the periphery by layers of highly vascularized membranes, the meninges. Although the brain has been considered immunoprivileged for decades, it has been recently shown by our team and others that the meninges are populated by a myriad of resident immune sentinels. The objective of this project is to understand how macrophages at the brain surface maintain neuronal functions. To address these questions, we will combine multiparametric flow cytometry, state-of-the-art single-cell transcriptomics, CRISPR-Cas9 technology, stereotactic injections and intravital imaging approaches. You will join a passionate, friendly and dynamic team, in an institute with state-of-the art equipment, at the border of the Calanques national park. The candidate should have a PhD in neuroscience. Experience with aforementioned techniques is appreciated but not mandatory. Applications should be sent to .

We are looking for an excellent, enthusiastic, and self-motivated early-career researchers with good communication skills to join our research team. We generally aim to understand how biological organisms organize soft material and we currently focus on the organization principles of liquid-like droplets in biological cells. However, we are also interested in broader questions in biological physics. Our work generally combines analytical insight from simple systems with more detailed numerical simulations to unveil biological design principles. Additionally, we build tailored models to interpret experimental data of collaborators. We offer multiple possible projects on these topics of theoretical biophysics. The successful candidate may also shape their own research direction.

We are looking for an excellent, enthusiastic, and self-motivated early-career researchers with good communication skills to join our research team. We generally aim to understand how biological organisms organize soft material and we currently focus on the organization principles of liquid-like droplets in biological cells. However, we are also interested in broader questions in biological physics. Our work generally combines analytical insight from simple systems with more detailed numerical simulations to unveil biological design principles. Additionally, we build tailored models to interpret experimental data of collaborators. We offer multiple possible projects on these topics of theoretical biophysics. The successful candidate may also shape their own research direction.

M. Madan Babu’s Group works with the Centre for Adipocyte Signaling (ADIPOSIGN) to understand the impact of natural genome variation on adipocyte signaling function and how changes in these signaling states during the development of obesity contribute to the pathophysiological consequences of obesity. ADIPOSIGN is run by Susanne Mandrup, Jan-Wilhelm Kornfeld, M. Madan Babu, and Zach Gerhart-Hines. We are looking for a candidate to develop and employ state-of-the-art computational genetics and genomics methods aimed at understanding the molecular basis of obesity phenotypes and how genetic variation contributes to the occurrence and development of obesity. The successful candidate will have a solid understanding of statistical genetics, strong programming skills, and a proven track record in large-scale human phenotype and genome variation data analysis and polygenic risk score calculation.

This is an excellent opportunity for postdoctoral researchers with a Euro-based salary. You'll have the chance to collaborate closely with your chosen supervisor to develop the project idea. Detailed information about this opportunity can be found at the following link. Mustafaoglu Lab is one of the host labs where you can choose to work, particularly if you are interested in developing projects related to the blood-brain barrier.

In this project we aim to increase understanding of the factors and molecular mechanisms that control ALT (alternative lengthening of telomeres). We will follow-up on recent unpublished findings from our lab, that implicate new factors in the regulation of ALT. In addition, we will investigate how ALT regulation by these factors can be exploited in treatment of ALT-positive pediatric cancers. We are looking for an ambitious and enthusiastic PhD candidate with a strong commitment to science and solid background in molecular biology and cell biology. The candidate should be creative, highly self-motivated, capable of independent thinking, have a problem-solving attitude and be a very good experimentalist. Good communication skills (oral and written) and ability to work together with others in an international team are essential. Previous experience in the fields of telomere maintenance, DNA replication and/or DNA damage and repair, would be advantageous, but are not an absolute must.