Studying gene regulation with quantitative and single-cell methods in dormant microbes.

Mechanisms underlying the maternal inheritance of mitochondrial DNA in Drosophila. www.findaphd.com/phds/project/probe-mechanisms-underlying-the-maternal-inheritance-of-mitochondrial-dna-in-drosophila/?p156141

A stimulating PhD position is available in the laboratory of Dr. Hind Medyouf at the Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus (Frankfurt, Germany). The research group is focused on exploring the role of the microenvironment in cancer.  

We have openings for two ERC funded postdoc positions, and are looking for talented highly motivated colleagues to join our international team. We uncovered a previously unrecognized cilium in meiosis, the zygotene cilium, in both males and females and in zebrafish and mouse, which mechanically controls meiotic chromosomal pairing and germ cell morphogenesis. The projects are part of an ambitious program to decipher the mechanisms of the zygotene cilium in the developing zebrafish gonads. Required qualifications: - A PhD in life sciences, cell and developmental biology and related fields - A strong track record in developmental biology and related fields - Expertise in zebrafish research and transgenesis - Experience in confocal microscopy is an advantage - Experience in single-cell transcriptomics / proteomics is an advantage - Excellent English - Strong communication skills www.yanivelkoubylab.com/postdoc-applcation-from

We are searching for motivated, curious, and independent individuals interested in joining us in Warsaw as PhD students to decipher mechanisms and physiological outcome of lipid-evoked regulation of proteostasis in the intestine.   grzegorzsumaralab.nencki.edu.pl/open-positions

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences (IMol) seeks group leader candidates, whose molecular biology research programmes will complement our existing research. IMol is a new research institute, led by profs. Agnieszka Chacińska and Magda Konarska, and it is in a phase of dynamic development. We offer a stimulating and interdisciplinary research environment and opportunities, access to state-of-the-art technology, excellent core facilities and supportive administration.   imol.institute/group-leader-positions

This purely computational project is broad and welcomes students who would like to pursue research into virus evolution and ecology, from the shortest timescales (genomic epidemiology/phylodynamics) involving very closely viral lineages within outbreaks to the longest timescales (long-term virus evolution) covering genome evolution and macroecology. Current lab interests cover genomic epidemiology of SARS-CoV-2 and long-term evolution of orthomyxoviruses and other negative sense single-stranded RNA viruses. Requirements: 1. Vilnius University requires applicants to have a Master's degree. 2. CV and list of publications. 3. Your research interests. Optional: 1. Programming - not necessary to have experience when applying but programming will be an integral part of the project and must be learned eventually. 2. If you are applying for this position from non-computational fields you should be able to justify the switch and what computational skills you hope to develop during the PhD.   tinyurl.com/Dudas-PhD

The candidate will work with patient derived CD34 cells and study the effect of gene editing on HbF up-regulation as a mechanism for treatment of Sickle cell Anemia and Beta Thallassemia. Previous experience with culturing and CRISPR manipulation of hematopoietic stem cells is desirable. The position is initially for 1 year and can be extended based on performance.

Employing single cell proteomics to study gene expression variability and its consequences for cellular survival under stressed conditions. This includes, but is not restricted to, studying how stress, due to chromosomal mis-segregation results in protein imbalance and toxicity. This will be studied in organoid model systems. Depending on the candidate, this may offer the possibility to develop an independent research line.

For details of the host lab see the application link below.

We are looking for a talented postdoctoral researcher for a project focusing on chromosome structure, function and dynamics during development. The project is conducted as a collaboration between the groups of Associate Professor Fukaya at Institute for Quantitative Biosciences (IQB), University of Tokyo, Japan, and Professor Camilla Björkegren, Department of Cell and Molecular Biology, Karolinska Institute (KI), Sweden.

A multidisciplinary project together with the Adamantidis laboratory that aims to identify molecular markers of brain activity during sleep using a range of neurophysiological techniques (Adamantidis) and mass spectrometry (MS)- based quantitative proteomics (Robles) (see doi:10.1126/science.aav2642; doi:10.1126/science.aav3617). We seek a motivated, enthusiastic, and talented postdoctoral researcher with experience with high-throughput quantitative proteomics approaches (single cell proteomics and DIA methods are a plus), able to operate nanoLC-HPLC and Thermo Orbitrap instruments, ability to perform large scale multi-omics data analysis and programming skills (R, Python), excellent written and oral communications skills in English (proficiency in German is a plus) and capable to work independently.

We are interested in studying how bunyaviruses, segmented negative-strand RNA viruses, reorganize and exploit cellular translation during infection. We want to identify which host factors are hijacked by viruses for their non-canonical translation strategies and to determine structures and function of the virus-host protein complexes involved.

We are interested in studying how bunyaviruses, segmented negative-strand RNA viruses, reorganize and exploit cellular translation during infection. We want to identify which host factors are hijacked by viruses for their non-canonical translation strategies and to determine structures and function of the virus-host protein complexes involved.