As a Junior Group Leader at IFOM, you will be part of the emerging wave of scientists involved in understanding the mechanistic bases of aging, preferentially in mammalian systems and with the ambition to make an impact on human conditions. You will be able to interact and complement established research groups in IFOM studying the mechanisms and impact of cellular senescence, telomere biology, cell plasticity and mechanobiology with the intent of establishing and contributing to thriving community in IFOM interested on aging. Applications are open until position is filled.

Applications are open until position is filled.

Applications are open until position is filled.

We know how phosphorylation drives DNA replication initiation. Dephosphorylation by protein phosphatases is also essential for DNA replication, but we do not understand why. The researcher appointed will examine how Protein Phosphatase 1 (PP1) and its regulatory proteins act in human cells to regulate DNA replication and ensure correct chromosome maintenance. We will examine how one PP1 regulator, NIPP1, affects DNA replication, using genome engineering and proteomics approaches to identify the substrates and pathways through which NIPP1 operates. We will additionally identify which other PP1 regulators control DNA replication. The position would suit a researcher interested in combining cell biological, genome engineering, biochemical and proteomics approaches to examine fundamental cellular processes. Applicants with experience in chromosome maintenance and genome stability analysis, genome engineering, proteomics, and/or DNA replication are particularly welcome.

The researcher appointed will examine how the RIF1 protein acts during DNA replication to ensure correct chromosome maintenance, taking forward recent breakthroughs concerning how RIF1 regulates DNA replication, and the cellular components it targets. RIF1 is multifunctional and its roles generally involve the regulation and targeting of Protein Phosphatase 1 (PP1), but in most cases the substrate for PP1-mediated dephosphorylation is not known. Collaborating with leading phosphatase researchers, we will take proteomic and substrate-trap approaches to identify the substrates and pathways through which RIF1 regulates chromosome maintenance. The position would particularly suit a postdoctoral researcher interested in combining molecular, biochemical, cellular, and proteomics approaches to address fundamental cellular processes. Applicants with prior experience in biochemistry, proteomics, DNA replication, genome stability, and/or structural analysis are particularly welcome.

Our team, “Polarity Division and Morphogenesis”, addresses emerging questions in the field of epithelial tissue development focusing on both genetic and mechanic regulations. In this context, we are looking for a highly motivated postdoctoral fellow to explore the mechanisms of cell division, mechano-sensing and morphogenesis in Drosophila using state-of-the art imaging methods, optogenetics, spatial transcriptomics and force measurements.