The Allen Frontiers Group funds a postdoctoral position in the Clausen Group, studying the impact of disease mutations on “Protein Lifespan”. Using novel types of reporters, we will monitor the fate of pathologic proteins in organismal context, focusing on myosin and its life cycle in the native muscle cell environment. We are looking for a postdoc to lead our C. elegans subgroup, mapping the proteostasis network implicated in aging-related protein disorders. The position comes with uncharted ubiquitin and autophagy territory, intricate molecular machines, and beautiful Vienna.

The Faculty of Engineering and Natural Sciences is searching for dynamic, innovative and qualified scholars for full-time faculty positions at all ranks to commence in the 2024-2025 academic year for the Molecular Biology, Genetics and Bioengineering (MBGB) program. Faculty members of the MBGB program have active research programs in a diverse range of research fields such as plant physiology and biotechnology, cellular and molecular biology, cancer molecular biology, computational biology, structural and systems biology, bioengineering, and tissue engineering. The MBGB program provides a dynamic and internationally competitive research environment with advanced research infrastructure.

The Intercollegiate Faculty of Biotechnology (IFB) is looking for external candidates for the position of Group Leader to establish new, independent research group and develop ambitious and innovative research programme at the cellular, molecular and biochemical levels, complementing the existing research at IFB.

The Intercollegiate Faculty of Biotechnology of the University of Gdansk and the Medical University of Gdansk (IFB UG & MUG) was established in 1993. The Faculty is a unique entity in Poland formed by two universities. IFB as well as both universities are constantly ranked as the highest quality considering research and teaching in Poland. The Faculty’s laboratories are located in the modern Institute of Biotechnology (UG Oliwa Campus) and the Institute of Medical Biotechnology and Experimental Oncology (MUG Campus). We are among the world pioneers in chaperone protein research, DNA replication, biogenesis and the degradation of protein complexes. Furthermore, we are a leading institution in Poland for conducting researchin molecular virology and bacterial plant pathogens. We are highly competitive in the fields of cancer research, immunology as well as photodynamic therapy. Access to the infrastructure of both universities, including core facilities and the most modern BSL3+ laboratory in Poland, offers a great opportunity for scientific development.

Replicative helicases are ring-like hexamers that are essential partners of replication in the 3 domains of life. They serve to unwind double strand DNA in front of the replication fork. The replicative helicase of bacteria, DnaB, is recruited at the unique origin of replication of the chromosome, oriC, by the initiator protein DnaA. In most bacteria, loading of DnaB on DNA is assisted by a conserved protein, DciA. The loading of DnaB was essentially studied in Escherichia coli and Bacillus subtilis, in which DciA has been replaced by phage-derived proteins, DnaC and DnaI, respectively. DnaC cracks open the preformed DnaB ring to place it on single strand DNA while DnaI assembles the 6 subunits of DnaB around DNA. The technician will participate to a project designed to decipher through cytological, genetic and genomic approaches how DciA ensure the loading of DnaB during replication initiation using as a model organism Vibrio cholerae.

Bacteria encode a highly conserved chromosomally encoded recombination (Xer) machinery, which serves to add crossovers at a specific site, dif. Numerous mobile elements exploit Xer to integrate into the dif site of one of their host chromosomes. Integrative Mobile Elements exploiting Xer (IMEX) are often associated to pathogenicity. A salient example is provided by the evolutionary history of the agent of the cholera, Vibrio cholerae. The diarrhoea that is responsible for the epidemic propagation and high death rate associated with cholera is encoded in the genome of an IMEX, the cholera toxin phage (CTX). CTX depends on another IMEX, the toxin-linked cryptic satellite phage, TLC, for integration. We showed that TLC encodes an activator of Xer recombination, XafT. The technician will participate to the structural characterization of XafT by a combined approach of molecular biology, biochemistry and single molecule analysis.  

Bacterial chromosomes contain a single origin of bidirectional replication, oriC, which defines two replication arms. As replication progresses along the two arms, newly replicated loci migrate to opposite halves of the cell. Yet, sister loci remain associated for a short period. In analogy to eukaryotes, this is referred to as cohesion. The team developed an NGS-based method to monitor sister chromatid cohesion at a high resolution along an entire genome, HiSC2. It revealed that the cohesion period is not constant along the bacterial chromosomes. In particular we found the Histone-like nucleoid structuring protein increased cohesion at the position of a pathogenicity island of Vibrio cholerae. The aims of the proposed work are to characterise the different factors involved in the local and global variations of sister chromatid cohesion along the genome of V. cholerae using a combination of whole-genome high-resolution NGS and fluorescence microscopy techniques.

We have obtained funding for two fully-paid Postdoc positions and one PhD position. Please follow the link for more information.

We have openings for two independent group leader positions (junior or established). Talented scientists are encouraged to apply. We strongly encourage applications from women scientists. Applications must be sent as a single PDF saved as LASTNAME_IGFL.pdf to . The deadline for applications is 31st December 2023.

Three PhD positions are available for either of our two research foci: 1. Evolution, life history, morphology and physiology of microalgae with key roles in carbon fixation 2. Genome evolution and regulation in giant viruses killing algae and other eukaryotes. Research experience in genomics, bioinformatics, evolutionary biology or microbiology is preferred but not required. To apply, please email (title: IPMB_application_PhD_YourName) to Chuan Ku, describing your research interests, experience, future plan and contact details of at least two referees, with your CV and relevant documents. Shortlisted candidates will be invited for an interview online and/or on-site. Stipend: 1,500-1,900 USD/month. Duration: 3–5 years. Working language: English.

We will characterize the Asgard eukaryotic-like protein homologs to establish their structural and functional relationships to their eukaryotic counterparts. Thus, these PhD projects will produce experimental data to address the origins of the eukaryotic cell. We use biochemical, biophysical and cell biology assays and mass spectrometry to compare the activities, and cross-activities, of Asgard and eukaryotic proteins. We also use bioinformatics, X-ray crystallography and cryo-electron microscopy to understand structural relationships. We are looking for research scientists with a burning desire for discovery that also possess natural empathy for others.

Our team investigates the algorithms and underlying neuronal basis of sensory navigation. We have discovered a sensory system detecting mechanical and chemical cues in the spinal cord (Wyart et al., Nature Rev Neurosci 2023). We now investigate how this sensory system influence neurogenesis after spinal cord injury. We are looking for a PDF with a strong expertise in molecular techniques (cloning, RNAseq, CRISPR/Cas-mediated genome editing in zebrafish, immunohistochemistry). Coding highly appreciated. The PDF will be trained in population calcium imaging, optogenetics and image analysis.