The project aims to define the genetic, genomic, and cell biological signature of the changes that occur as cells transition from free-living to symbiosis. This will include characterizing gene expression, proteomic, genome structural, and morphological changes of the dinoflagellate cell as it undergoes this transition.

Investigating the molecular mechanisms of light-driven DNA damage repair mechanisms in Aiptasia, a model for coral symbiosis. Requirements: MSc in Molecular Biology, Cell Biology, Genetics, Biochemistry (or similar).

The heterochromatin factor KAP1 plays important roles in telomere protection, gene repression and DNA repair. By following-up on recent findings from our group we will aim to increase our understanding of how KAP1 contributes to genome stability maintenance. We will study how KAP1 activity is controlled by novel regulators of KAP1 that we recently identified in genetic screens. Moreover, we will study how cancer cells benefit from KAP1 overexpression and how this may potentially be exploited therapeutically. We are looking for an ambitious and enthusiastic PhD candidate with a strong commitment to science and solid background in molecular biology and cell biology. The candidate should be creative, highly self-motivated, capable of independent thinking, have a problem-solving attitude and be a very good experimentalist. Good communication skills (oral and written) and ability to work together with others in an international team are essential.

The main goal of the project is to understand the establishment of endosymbiosis by identifying and characterizing novel protist-endosymbiont systems at intermediate stages of endosymbiosis. We will screen various freshwater environments for such interactions and isolate and identify the partners using microscopic and genetic methods. The organisms in the intermediate stages of endosymbiosis will be studied at the level of genome evolution and regulation of gene expression that accompanies the endosymbiotic interaction. We will also study the ultrastructure of the studied cells, which – together with the genetic information – will reveal the nature of the studied systems. The ideal post-doctoral candidate will have a strong interest in evolutionary biology and microbial eukaryotes (protists). Experience in laboratory work and/or sampling and research experience in culturing microorganisms and microscopy and/or bioinformatics and genomic analysis is required.

Physical and quantitative-biology approaches to understanding slowed/suspended lives of cells (spores, etc.). Contact the lab for more details.

The successful candidate will develop AI tools for the analysis of developmental trajectories (normal and perturbed) and combine them with the spatial embedding of cell states (described by single-cell omics) to not only predict normal and aberrant developmental trajectories, but also to explain the causes of embryonic developmental variability as a combination of cellular interactions in space and time. The successful candidate will be expected to make a significant contribution to the design of the project. In addition, the successful candidate will be involved in the activities of ALMIA, the Advanced Light Microscopy and Image Analysis Platform of CABD, to provide technical and scientific advice to CABD researchers. The candidate is expected to have a Ph.D. with expertise in image analysis, preferably biological, using artificial intelligence, and an excellent track record. Fluency in English is required. Experience in live imaging, quantitative and computational biology, or single cell omics is a plus. Start of contract: Before 31 December 2024 Email: (preferred mean of contact; Mention in subject “Momentum Postdoctoral”. Interested candidates, please, contact as soon as possible

A Staff Scientist Position (Computational Biologist / Bioinformatician): Innovative Computational Methods for the Analysis of Microbiome Data (m/f/d). The group “Innate Immune Regulation in cancer and stem cell transplantation“ (headed by Prof. Dr. Hendrik Poeck) at the Klinik und Poliklinik Innere Medizin 3, University Hospital of Regensburg (UKR), offers a Staff Scientist position to applicants with enthusiasm for academic research. The position is full-time (40.1 hours per week) and is remunerated on the TV-L salary scale (TV-L EG 13). The position can also be filled part-time. The position will be embedded in the Next-Generation-Sequencing Core Facility (headed by Prof. Dr. Michael Rehli) of the Leibniz Institute for Immunotherapy (LIT). The NGS Core Facility supports LIT researchers in high-throughput data generation, processing, analysis, visualization and interpretation, as well as by providing IT infrastructure, software training and consulting services.

Extracellular vesicles (EVs) are organelles resembling viruses (often refer to as ‘exosomes’). EVs mediate cell-tocell communication and are also appreciated for their potential diagnostic and therapeutic applications. Yet, molecular mechanisms supporting EV activities are poorly understood precluding their rational use. The project aims to better understand EV signaling mechanisms and how EV-based therapies should be designed to increase EV-activity and specificity. The project is suitable for life science students with interests in molecular and cellular biology – biochemistry and/or biophysics. The candidate should be highly motivated to learn and apply complementary technological approaches related to EV-analysis and to develop a strong analytical and critical mind. The position is initially funded for 1 year (~2600 €/m) and intended to support the applicant to obtain his/her own fellowship. If the candidate shows high scientific potential up to 3-4 years extra funding is foreseen. Candidates should send their CV and contact information for up to three references to: Prof. Pascale ZIMMERMANN Subject: PhD-EV-signaling More information about the work of the laboratory: Web of Science Researcher ID P-4190-2017 ORCID 0000-0001- 8768-1790 gbiomed.kuleuven.be/english/cme/research/research www.crcm-marseille.fr/en/teams/research-teams/pascale-zimmermann

Two postdoctoral positions are available in the Alimonti lab to be part of an ongoing effort to elucidate the role of gut and intratumoral microbiota in cancer. The successful candidates will use and implement an innovative proprietary microfluidic platform to identify bacterial products with anti-cancer properties, apply different approaches (10X genomics single cell, metagenomics, proteomics, metabolomics, drug screenings) and generate novel mouse models to understand how bacteria and fungi control prostate tumor development. We offer a vibrant environment of scientists. We look for highly motivated candidates with outstanding basic and cancer biology and proven microbiology expertise. Experience with in vivo cancer models is mandatory, bioinformatics knowledge is a plus. We require at least one first-author original research publication in a high IF journal, the ability to work independently, interact with colleagues with different backgrounds, and establish relevant collaborations.