We have an attractive, ERC funded postdoc position available, to study how metabolism shapes drug tolerance. We study the problem in C. albicans, and have sequenced and characterized a huge collection of yeast isolates for this purpose. Our favorite technology is mass spectrometry based proteomics, and we are adressing this problem using system-level approaches.

Cellular and molecular biology of axonal transport related to neurotransmission. Use of biosensors, videomicroscopy, microfluidic devices, and mice. Please contact Frédéric Saudou directly.

You will manage a research project to study how DNA replication and repair mechanisms influence haematopoeitic stem cell (HSCs) self-renewal and lineage commitment equilibria in mammals. The project will consider physiological sources of DNA damage that affect the HSC compartment, including DNA demethylation-associated programmed base oxidation by TET (Ten-eleven Translocase) enzymes, telomere attrition, and exposure to endogenous mutagens and genotoxic metabolites. You will hold a PhD (or near completion: thesis submitted at the time of application) in stem cell, chromosome and/or genome stability biology. Proven experience in advanced flow cytometry and or NGS methodologies, genome manipulation (e.g. directed and/or genome-wide CRISPR approaches), FACS and single cell analyses, is essential. You will also have relevant specialist laboratory experience in molecular and cell biology, mouse and molecular genetics, and in vivo studies, ideally related to haematopoiesis.

We study the dynamic regulation of proteolytic pathways that integrate environmental and physiological changes to identify protein degradation networks that protect the proteome of the organism. Your profile:

• A Ph.D. in biology, biochemistry or a related field and experience in organismal biology are required
• Strong interest in protein quality control and aging research
• Highly intrinsically motivated, creative, dedicated, and critical thinker
• Ability to clearly communicate research results to other lab members
• Excellent oral and written communication skills in English
• Team player who can work independently in an international team
• Proactive, flexible, and problem-solving attitude

Your tasks:

• Design and lead research projects to elucidate mechanisms of protein quality control and degradation of damaged proteins
• Advise and mentor undergraduate, graduate, and PhD students

Please contact Kinga directly to discuss the position.

The postdoctoral researcher will be responsible for multi-omic analysis of the fibrotic processes in the host, with a particular focus on the liver stellate cells and the impact of the microbiota.

Two full-time postdoc positions are available in the laboratory of Dr. Zuzana Keckesova. Our lab aims to identify and characterize new tumor suppressor pathways in human cells and translate this new knowledge into therapeutic use. We are looking for enthusiastic, independent and highly-motivated postdoctoral associates with a background in cancer biology, molecular biology, metabolism, or biochemistry. Good English speaking skills and experience with tissue culture are necessary. Institute is multi-national and managed in the English language. We offer:

• Good salary
• Five weeks holiday
• Health insurance and full benefits package incl. contribution to pension, culture, and sport

The position will be initially for 1 year with the possibility of extending to 5 years. The starting date is anytime between September 2024 until March 2025. Interested candidates should submit their cover letter and CV including names and contact information of two references to

The brain surface is connected to the periphery by the meninges, previously thought to be an inert tissue. Revolutionizing findings reveal that the meninges are populated by resident immune sentinels, crucial for neuronal function, tissue homeostasis and protection, and thus involved in neurological diseases. Meningeal macrophages are fascinating cells, pivotal in CNS function and dysfunction, though their properties remain largely unknown. This project aims to explore how these macrophages support neuronal functions and how that affects mouse cognition. The research will utilize multiparametric flow cytometry, single-cell transcriptomics, CRISPR-Cas9, stereotactic injections, and intravital imaging in wild-type and transgenic mice. The team offers a dynamic, well-equipped environment near Calanques National Park, France. Applicants with a PhD in immunology or neuroscience and should contact .

DBS is an exciting collaborative, interdisciplinary and multi-species initiative at the Paris Brain Institute. By bridging approaches from human genetics, cellular neurobiology, computational approaches, physiology of motor circuits from genetic model organisms to humans, our aim is to build novel strategies to stimulate resilient motor circuits in Parkinson’s disease. The originality of the DBS project lies in its interdisciplinary approach involving duos of researchers from different fields of neuroscience with very different backgrounds who will closely train the next generation of postdoctoral fellows.

The successful candidate will develop AI tools for the analysis of developmental trajectories (normal and perturbed) and combine them with the spatial embedding of cell states (described by single-cell omics) to not only predict normal and aberrant developmental trajectories, but also to explain the causes of embryonic developmental variability as a combination of cellular interactions in space and time. The successful candidate will be expected to make a significant contribution to the design of the project. In addition, the successful candidate will be involved in the activities of ALMIA, the Advanced Light Microscopy and Image Analysis Platform of CABD, to provide technical and scientific advice to CABD researchers. The candidate is expected to have a Ph.D. with expertise in image analysis, preferably biological, using artificial intelligence, and an excellent track record. Fluency in English is required. Experience in live imaging, quantitative and computational biology, or single cell omics is a plus. Start of contract: Before 31 December 2024 Email: (preferred mean of contact; Mention in subject “Momentum Postdoctoral”. Interested candidates, please, contact as soon as possible

The heterochromatin factor KAP1 plays important roles in telomere protection, gene repression and DNA repair. By following-up on recent findings from our group we will aim to increase our understanding of how KAP1 contributes to genome stability maintenance. We will study how KAP1 activity is controlled by novel regulators of KAP1 that we recently identified in genetic screens. Moreover, we will study how cancer cells benefit from KAP1 overexpression and how this may potentially be exploited therapeutically. We are looking for an ambitious and enthusiastic PhD candidate with a strong commitment to science and solid background in molecular biology and cell biology. The candidate should be creative, highly self-motivated, capable of independent thinking, have a problem-solving attitude and be a very good experimentalist. Good communication skills (oral and written) and ability to work together with others in an international team are essential.

The main goal of the project is to understand the establishment of endosymbiosis by identifying and characterizing novel protist-endosymbiont systems at intermediate stages of endosymbiosis. We will screen various freshwater environments for such interactions and isolate and identify the partners using microscopic and genetic methods. The organisms in the intermediate stages of endosymbiosis will be studied at the level of genome evolution and regulation of gene expression that accompanies the endosymbiotic interaction. We will also study the ultrastructure of the studied cells, which – together with the genetic information – will reveal the nature of the studied systems. The ideal post-doctoral candidate will have a strong interest in evolutionary biology and microbial eukaryotes (protists). Experience in laboratory work and/or sampling and research experience in culturing microorganisms and microscopy and/or bioinformatics and genomic analysis is required.

Physical and quantitative-biology approaches to understanding slowed/suspended lives of cells (spores, etc.). Contact the lab for more details.

Two postdoctoral positions are available in the Alimonti lab to be part of an ongoing effort to elucidate the role of gut and intratumoral microbiota in cancer. The successful candidates will use and implement an innovative proprietary microfluidic platform to identify bacterial products with anti-cancer properties, apply different approaches (10X genomics single cell, metagenomics, proteomics, metabolomics, drug screenings) and generate novel mouse models to understand how bacteria and fungi control prostate tumor development. We offer a vibrant environment of scientists. We look for highly motivated candidates with outstanding basic and cancer biology and proven microbiology expertise. Experience with in vivo cancer models is mandatory, bioinformatics knowledge is a plus. We require at least one first-author original research publication in a high IF journal, the ability to work independently, interact with colleagues with different backgrounds, and establish relevant collaborations.