There is a new postdoc position available in the laboratory of Romeo Ricci at the IGBMC in Strasbourg, France (https://www.igbmc.fr/en/recherche/teams/signal-transduction-in-metabolism-and-inflammation). We offer an exciting project dealing with mechanisms underlying endosomal activation of NLRP3 based on our latest publication in Nature Immunology. The candidate will initially be hired for one year according to French salary schemes. Prolongation for two more years will be possible. However, applications for competitive fellowships will be strongly encouraged during the first year of recruitment. Ideally, the recruitment should be accomplished by the end of 2023 or beginning of 2024. Candidates shortly after their PhD thesis with experience in innate immunity and/or cell biology are particularly welcome to apply. Female scientists are particularly encouraged to submit their application. Disabled applicants will be preferentially considered in case of equivalent qualification.

We are looking for a postdoctoral fellow to join our ongoing exploration of human innate immune pathways. We welcome applications from PhD scientists with background in immunology, molecular biology and dermatology. Experience with CRISPR screening and animal models of diseases is preferred. Please contact 'franklin.zhong AT ntu.edu.sg' directly.

We are recruiting postdoctoral researchers with experience in biophysics, cell and developmental biology and advanced fluorescence microscopy. The candidates will work within an ERC funded project that investigates the role of geometry and mechanical forces in early embryo development and multicellular self-organization. In vivo methods and synthetic biology approaches will be employed to study the influence of shape, size, and cellular mechanosignalling in tissue patterning and robust morphogenesis during early embryo development.

The successful candidate will combine cutting-edge mouse genetics with cell biology and -omics approaches to disentangle how excessive nutrient levels and aberrant nutrient signaling corrupt cellular and systemic metabolism to promote cancer and aging. Previous experience in mouse genetics, signal transduction, cancer biology or metabolism will be positively evaluated.

We are looking for self-motivated and enthusiastic scientists with a PhD in a relevant field, with a strong background in cell biology, biochemistry or structural biology.

The candidate will lead research into the evolution of life history traits in Killifish, with a strong emphasis on extreme longevity. Leveraging our group's past work, which dissected adaptive and neutral forces in Killifish life history trait evolution, the Postdoctoral Researcher will conduct in-depth genomic and proteomic analyses. They will develop and test models explaining extreme longevity in Turquoise Killifish (Nothobranchius furzeri). A multidisciplinary approach, merging population genetics, statistical genetics, genomics, evolutionary ecology, data science, and physics, will be essential.

This candidate will explore microbiome-host interactions during aging, a core research team in the Valenzano group. This work will be integrated as part of the research focus “functional microbiome interactions in aging”, which consists of four research teams at the FLI. The candidate is asked to adopt a multi-disciplinary approach, which involves molecular cloning, culturomics, classical microbiology, as well as high-throughput screening of microbial isolates, phage isolation and microbial metagenomics.

We are seeking a postdoctoral researcher to investigate the neuronal and molecular mechanisms of Intellectual Disability (ID) and Autism Spectrum Disorder (ASD) using Drosophila as a model. The project focuses on habituation, a conserved form of learning that protects the brain from sensory overload and stands at the base of higher cognitive function. Requirements: Ph.D. in neuroscience or genetics; experience with Drosophila neurobiology, circuit biology, optogenetics and/or computational neuroscience is a plus; self-motivation, efficiency and reliability; great organization and project management skills; team worker who values a positive work environment; excellent English written and oral communication skills; start from 1.10. 2023 (negotiable)

A postdoctoral position is available in the group of Dr. Bonnie Murphy at the Max Planck Institute of Biophysics in Frankfurt, Germany to work within the ERC-funded project REEL-EM. The project aims to develop techniques for elemental mapping within cryo-preserved macromolecular complexes. The approach brings together the methods of analytical electron microscopy with the powerful image processing tools of single-particle analysis, allowing these traditionally high-dose techniques to be applied to dose-sensitive biological samples. Our Proof-of-principle data show that our approach can generate elemental maps of more abundant elements within cryo-preserved macromolecular complexes, imaged at doses below 100 e-/Å2. The candidate will join a team working together to advance the sensitivity and resolution of the technique and to implement and improve workflows for efficient image acquisition and processing. recruitingapp-5577.de.umantis.com/Vacancies/290/Description/2

Replicative helicases are ring-like hexamers that are essential partners of replication in the 3 domains of life. They serve to unwind double strand DNA in front of the replication fork. The replicative helicase of bacteria, DnaB, is recruited at the unique origin of replication of the chromosome, oriC, by the initiator protein DnaA. In most bacteria, loading of DnaB on DNA is assisted by a conserved protein, DciA. The loading of DnaB was essentially studied in Escherichia coli and Bacillus subtilis, in which DciA has been replaced by phage-derived proteins, DnaC and DnaI, respectively. DnaC cracks open the preformed DnaB ring to place it on single strand DNA while DnaI assembles the 6 subunits of DnaB around DNA. The technician will participate to a project designed to decipher through cytological, genetic and genomic approaches how DciA ensure the loading of DnaB during replication initiation using as a model organism Vibrio cholerae.

Bacteria encode a highly conserved chromosomally encoded recombination (Xer) machinery, which serves to add crossovers at a specific site, dif. Numerous mobile elements exploit Xer to integrate into the dif site of one of their host chromosomes. Integrative Mobile Elements exploiting Xer (IMEX) are often associated to pathogenicity. A salient example is provided by the evolutionary history of the agent of the cholera, Vibrio cholerae. The diarrhoea that is responsible for the epidemic propagation and high death rate associated with cholera is encoded in the genome of an IMEX, the cholera toxin phage (CTX). CTX depends on another IMEX, the toxin-linked cryptic satellite phage, TLC, for integration. We showed that TLC encodes an activator of Xer recombination, XafT. The technician will participate to the structural characterization of XafT by a combined approach of molecular biology, biochemistry and single molecule analysis.  

Bacterial chromosomes contain a single origin of bidirectional replication, oriC, which defines two replication arms. As replication progresses along the two arms, newly replicated loci migrate to opposite halves of the cell. Yet, sister loci remain associated for a short period. In analogy to eukaryotes, this is referred to as cohesion. The team developed an NGS-based method to monitor sister chromatid cohesion at a high resolution along an entire genome, HiSC2. It revealed that the cohesion period is not constant along the bacterial chromosomes. In particular we found the Histone-like nucleoid structuring protein increased cohesion at the position of a pathogenicity island of Vibrio cholerae. The aims of the proposed work are to characterise the different factors involved in the local and global variations of sister chromatid cohesion along the genome of V. cholerae using a combination of whole-genome high-resolution NGS and fluorescence microscopy techniques.

We have obtained funding for two fully-paid Postdoc positions and one PhD position. Please follow the link for more information.

We have openings for two independent group leader positions (junior or established). Talented scientists are encouraged to apply. We strongly encourage applications from women scientists. Applications must be sent as a single PDF saved as LASTNAME_IGFL.pdf to . The deadline for applications is 31st December 2023.