The Harel Lab investigates fundamental questions in aging research, including why aging is a major driver of disease and the molecular basis behind the remarkable diversity in vertebrate lifespans, which can vary by up to 1,000-fold. To address these questions, we develop advanced genome engineering techniques for the naturally short-lived turquoise killifish model. We also employ cutting-edge in vivo imaging, single-cell and computational approaches, and disease modeling in mammalian systems.