M. Madan Babu’s Group works with the Centre for Adipocyte Signaling (ADIPOSIGN) to understand the impact of natural genome variation on adipocyte signaling function and how changes in these signaling states during the development of obesity contribute to the pathophysiological consequences of obesity. ADIPOSIGN is run by Susanne Mandrup, Jan-Wilhelm Kornfeld, M. Madan Babu, and Zach Gerhart-Hines. We are looking for a candidate to develop and employ state-of-the-art computational genetics and genomics methods aimed at understanding the molecular basis of obesity phenotypes and how genetic variation contributes to the occurrence and development of obesity. The successful candidate will have a solid understanding of statistical genetics, strong programming skills, and a proven track record in large-scale human phenotype and genome variation data analysis and polygenic risk score calculation.

This is an excellent opportunity for postdoctoral researchers with a Euro-based salary. You'll have the chance to collaborate closely with your chosen supervisor to develop the project idea. Detailed information about this opportunity can be found at the following link. Mustafaoglu Lab is one of the host labs where you can choose to work, particularly if you are interested in developing projects related to the blood-brain barrier.

In this project we aim to increase understanding of the factors and molecular mechanisms that control ALT (alternative lengthening of telomeres). We will follow-up on recent unpublished findings from our lab, that implicate new factors in the regulation of ALT. In addition, we will investigate how ALT regulation by these factors can be exploited in treatment of ALT-positive pediatric cancers. We are looking for an ambitious and enthusiastic PhD candidate with a strong commitment to science and solid background in molecular biology and cell biology. The candidate should be creative, highly self-motivated, capable of independent thinking, have a problem-solving attitude and be a very good experimentalist. Good communication skills (oral and written) and ability to work together with others in an international team are essential. Previous experience in the fields of telomere maintenance, DNA replication and/or DNA damage and repair, would be advantageous, but are not an absolute must.