YIP News

Recently published papers by Young Investigators

B Cell Ligand Discrimination Through a Spreading and Contraction Response
Science 5 May 2006:
Vol. 312. no. 5774, pp. 738 - 741
DOI: 10.1126/science.1123940

S. J. Fleire,1 J. P. Goldman,2,3 Y. R. Carrasco,1 M. Weber,1 D. Bray,3 F. D. Batista1*

B cells recognize foreign antigens by virtue of cell surface immunoglobulin receptors and are most effectively activated by membrane-bound ligands. Here, we show that in the early stages of this process, B cells exhibit a two-phase response in which they first spread over the antigen-bearing membrane and then contract, thereby collecting bound antigen into a central aggregate. The extent of this response, which is both signaling- and actin-dependent, determines the quantity of antigen accumulated and hence the degree of B cell activation. Brownian dynamic simulations reproduce essential features of the antigen collection process and suggest a possible basis for affinity discrimination. We propose that dynamic spreading is an important step of the immune response.

1 Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.

2 Computing Laboratory, University of Kent, Canterbury CT2 7NF, UK.

3 Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

* Correspondence should be addressed to : E-mail: facundo.batista@cancer.org.uk

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.
Nature Cell Biology 8, 358 - 366 (2006)
Published online: 12 March 2006; | doi:10.1038/ncb1382

Agnieszka Gambus1, Richard C. Jones2, 3, Alberto Sanchez-Diaz1, 3, Masato Kanemaki1, Frederick van Deursen1, Ricky D. Edmondson2 & Karim Labib1

1 Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

2 Food and Drug Administration, National Center for Toxicological Research (FDA/NCTR), 3900 NCTR Road, Jefferson, AR 72079, USA.

3 These authors contributed equally to this work.

Correspondence should be addressed to: Karim Labib klabib@picr.man.ac.uk

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Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks
The EMBO Journal (2006) 25, 1753–1763, doi:10.1038/sj.emboj.7601063

Masato Kanemaki and Karim Labib

Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK

Correspondence should be addressed to :
Karim Labib, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
Tel.: +44 161 446 8168; Fax: +44 161 446 3109;
E-mail: klabib@picr.man.ac.uk

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