AWARDS – A gOOD READ – AppOINTMENTS AWARDS – A gOOD READ – AppOINTMENTS Awards of excellence Events EMBO MEMBERS & FELLOWS EMBO Member Frank Grosveld is one of the organizers of the conference Epigenetics & Chromatin: Interactions and processes to be held at the Harvard Medical School in Boston, United States, on 11 – 13 March 2013. More at: www.epigenetic- sandchromatin.com/conf Cellular Polarity – From Mechanisms to Disease is the title of a two-day scientific discussion meeting at the Royal Society London on 15 – 16 April 2013. The conference is free to attend. More at: http://royalsociety.org/events/ 2013/cellular-polarity/ EMBO MEMBERS Royal Irish Academy Gold Medals 2012 Luke O’Neill was the recipient of one of two Royal Irish Academy Gold Medals for 2012. Professor O’Neill from Trinity College Dublin, Ireland, was recognised for his outstanding contributions in the fields of immunology and inflammatory diseases such as rheumatoid arthritis. The Royal Irish Academy Gold Medals are awarded to two outstanding academics each year and recog- nised as “a truly national expres- sion of celebration for scholarly achievement.” Gottfried Wilhelm Leibniz Prize 2013 EMBO Member Ivan Dikic from the University of Frankfurt is to receive the Leibniz Prize 2013 – Germany’s most prestigious research award worth 2.5 million euros. He was recognized for his essential contributions to understanding the function of the protein ubiquitin complex and its role in molecular processes like DNA repair and congenital immunity. The Leibniz Prize will be awarded to a total of eleven scientists and presented on 19 March 2013 in Berlin. Marcel Benoist Prize 2012 Michael N. Hall, professor of Biochemistry at the Biozentrum of the University of Basel, received this award for his outstanding research in the field of cell biology on cell growth and carcinogen- esis. The Marcel Benoist prize is the oldest scientific award in Switzerland and is regarded as the highest recognition for outstanding achievements in the sciences and the humanities. Inserm Grand Prize 2012 The recipient of the 2012 Inserm Grand Prize is Philippe Sansonetti from the Institut Pasteur in Paris, in recognition of his research on microbial infec- tion. The grand prize is awarded each year to honour a member of the scientific research community whose work has contributed to advancing knowledge of human physiology, therapeutics and health in general. Inserm International Prize 2012 The recipient of Inserm’s International Prize is Ingrid Grummt of the German Cancer Research Centre in Heidelberg in recognition of her epigenetics research on the molecular mechanisms that regulate gene expression. Howard Hughes Medical Institute (HHMI) Senior International Research Scholars Pascale Cossart, Alberto R. Kornblihtt, Philippe Sansonetti and Dominique Soldati-Favre were among the thirteen life scientists selected as HHMI Senior International Research Scholars in 2012. Each of them will receive a grant of 100,000 US-dollars per year over five years, and will present their research at scien- tific meetings held at HHMI. The awards support scientists working outside the United States who have made significant contribu- tions to fundamental research in the biological sciences. US National Medal of Science Associate Member Leroy Hood from the Institute for Systems Biology in Seattle, United States, was among the twelve scientists recognized with the National Medal of Science, the highest scientific honour in the United States. Hood received the award from President Obama in a White House ceremony in early 2013. European Federation of Medicinal Chemistry (EFMC) 2012 Nauta Award for Pharmacochemistry Alexander Levitzki, professor emeritus at the Hebrew University of Jerusalem, Israel, is the recipi- ent of the 2012 Nauta Award for outstanding achievements in the field of Medicinal Chemistry. By awarding the Nauta prize, the EFMC acknowledges and recog- nizes outstanding achievements in the advancement of Medicinal Chemistry and the development of international organizational structures in this field. Erwin Schrödinger Prize 2012 Jürgen Knoblich, Senior Scientist and Deputy Scientific Director at the Institute of Molecular Biology in Vienna, Austria, received the 2012 Erwin Schrödinger Prize of the Austrian Academy of Sciences for his research on the molecular mechanisms responsible for asymmetric stem cell division. The Erwin Schrödinger Prize is an annual award for lifetime achieve- ment by Austrians in the fields of mathematics and natural sciences. Universidad de la República Doctor Honoris Causa Giorgio Bernardi from the Roma Tre University received a Honorary Degree (Doctor Honoris Causa) from the Universidad de la República in Montevideo, Uruguay, in October 2012. Fellow Alessandra Cambi is co-organizing the meeting Visualizing signaling nanoplat- forms at a higher spatiotemporal resolution that will be held in Barcelona on 29 – 31 May 2013. Topics covered include Superresolution Techniques: From Methods to Data Analysis; Lipids, Protein Nanoislands and the Role of the Cytoskeleton; and Dynamics in Signalling Nanoplatforms. Detailed informa- tion and registration available at: www.icrea-signano2013.com Ioannis Trougakos, Vassilis Gorgoulis and EMBO Members Thanos Halazonetis and Luca Scorrano are organizing an International Workshop on Ageing and Cancer Cell Biology. The meeting, which will take place in Athens, Greece on 27–29 June 2013, brings together experts from Europe and the USA to discuss the molecular mechanisms at the interface of ageing and cancer. Topics will include senescence, DNA replication stress and ageing in model organisms and humans. The venue of the workshop is the amphitheater of the spectacular new Acropolis Museum (www.theacropolismuseum.gr/en). More at: www.ageing-cancer.inspire.uoa.gr A good read – Publications from the EMBO Community EMBO MEMBERS, YOUNG INvESTIGATORS & FELLOWS Obesity-induced overexpres- sion of miR-802 impairs glucose metabolism through silencing of Hnf1b Jan-Wilhelm Kornfeld (EMBO Fellow), Jens C. Brüning (EMBO Member), Markus Stoffel (EMBO Member) et al. Nature | 7 February 2013 Genetic identification of C-fibres that detect massage-like strok- ing of hairy skin in vivo Sophia Vrontou (EMBO Fellow) et al. Nature | 31 January 2013 doi: 10.1038/nature11810 Molecular signatures of G protein-coupled receptors M. Madan Babu (EMBO Young Investigator) et al. Nature | February 2013 doi: 10.1038/nature11896 Spatial regulation of vEGF recep- tor endocytosis in angiogenesis Masanori Nakayama (EMBO Fellow) et al. Nature Cell Biology | 27 January 2013 doi:10.1038/ncb2679 Appointments EMBO MEMBER Thomas Graf, leader of the Hematopoietic Stem Cell Biology and Differentiation group at the Centre for Genomic Regulation in Barcelona, Spain, has been appointed associated editor of the journal Stem Cell Reports. The new online, open-access journal is an initiative of the International Society for Stem Cell Research (ISSCR) and Cell Press. The first issue will be published in June 2013. Douglas Higgs was appointed new director of the Medical Research Council Weatherall Structural basis for 5’-triphos- phate viral RNA recognition by human IFIT proteins Andreas Pichlmair (EMBO Fellow), Giulio Superti-Furga (EMBO Member) et al. Nature | 13 January 2013 doi:10.1038/nature11783 Molecular mechanism of action of microtubule-stabilizing anti- cancer agents Michel O. Steinmetz (EMBO Member) et al. Science | 3 January 2013 doi:10.1126/science.1230582 Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding Sebastian Pechmann (EMBO Fellow) et al. Nature Structural & Molecular Biology 23 December 2012 doi: 10.1038/nsmb.2466 Systematic genetic interaction screens uncover cell polar- ity regulators and functional redundancy Bruno Thomas Fievet (EMBO Fellow), Julie Ahringer (EMBO Member) et al. Nature Cell Biology | 16 December 2012 doi:10.1038/ncb2639 Institute of Molecular Medicine (WIMM) at the University of Oxford. Higgs, formerly director of the MRC Molecular Haematology Unit at the WIMM, took up the role in December 2012 after the retirement of Sir Andrew McMichael. “A successful institute continually needs to recruit excit- ing new scientists, and I plan to recruit a new chair of molecular medicine and new MRC-funded research fellows over the next few years,” said professor Higgs. “I also plan to strengthen our links to the clinical service in the adjacent John Radcliffe Hospital and develop key aspects of the WIMM Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis Bruce Morgan (EMBO Fellow) et al. Nature Chemical Biology | 16 December 2012 doi:10.1038/nchembio.1142 Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis Mark Petronczki (EMBO Young Investigator) and Sergey Lekomtsev (EMBO Fellow) et al. Nature | 12 December 2012 doi:10.1038/nature11773 Ubiquitin chain conformation regulates recognition and activity of interacting proteins David Komander (EMBO Young Investigator) et al. Nature | 2 December 2012 doi: 10.1038/nature11722 Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis Sebastian Jessberger (EMBO Young Investigator) et al. Nature | 2 December 2012 doi:10.1038/nature11689 infrastructure that will enable our researchers to apply state-of-the- art technology to all aspects of our research.” Sarah Teichmann from the MRC Laboratory of Molecular Biology in Cambridge will move to the European Bioinformatics Institute (EBI) in Hinxton, UK, with a joint appointment at the Wellcome Trust Sanger Institute as of February 2013. It is the first such joint appointment between the two institutes in Hinxton. Next issue The next EMBOencounters issue – Summer 2013 – will be dispatched in July 2013. Please send your suggestions, contributions and news, to communications@embo.org by 6 May 2013. 16 EMBOencounters | Winter 2012|2013 | communications@embo.org ©2013 EMBO